Literature summary extracted from

Bergo, M.O.; Lieu, H.D.; Gavino, B.J.; Ambroziak, P.; Otto, J.C.; Casey, P.J.; Walker, Q.M.; Young, S.G.
On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy (2004), J. Biol. Chem., 279, 4729-4736.

Application

EC Number	Application	Comment	Organism
3.4.99.B1	medicine	Rce1 knockout mice have a dilated cardiomyopathy, by contrast, liver-specific Rce1 knockout mice appear healthy, endoproteolytic processing of CAAX proteins is essential for cardiac function but less important for the liver	Mus musculus

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.99.B1	additional information	heart specific and liver specific Rce1 knockout mice	Mus musculus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.99.B1	endoplasmic reticulum	-	Mus musculus	5783	-
3.4.99.B1	membrane	-	Mus musculus	16020	-
3.4.99.B1	additional information	fibroblast	Mus musculus	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.99.B1	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.99.B1	heart	-	Mus musculus	-
3.4.99.B1	liver	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.99.B1	a-factor-CaaX + H2O	-	Mus musculus	a-factor-C + aaX	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.99.B1	RCE1	-	Mus musculus

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Release 2023.1 (January 2023)